Human SARS-coronavirus RNA-dependent RNA polymerase: Activity determinants and nucleoside analogue inhibitors
نویسندگان
چکیده
منابع مشابه
A second, non-canonical RNA-dependent RNA polymerase in SARS coronavirus.
In (+) RNA coronaviruses, replication and transcription of the giant approximately 30 kb genome to produce genome- and subgenome-size RNAs of both polarities are mediated by a cognate membrane-bound enzymatic complex. Its RNA-dependent RNA polymerase (RdRp) activity appears to be supplied by non-structural protein 12 (nsp12) that includes an RdRp domain conserved in all RNA viruses. Using SARS ...
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ژورنال
عنوان ژورنال: Proteins: Structure, Function, and Bioinformatics
سال: 2004
ISSN: 0887-3585
DOI: 10.1002/prot.20194